Cardioprotection During Cardiopulmonary Bypass

Significant acute global iri during cardiac bypass surgery resulting in increased risk of pmi impaired lv systolic function and worsened morbidity and mortality.

Cardioprotection during cardiopulmonary bypass. A cardiopulmonary bypass machine cbm is commonly known as a heart lung bypass machine. The finding that cardiopulmonary bypass triggers cardiac injury prior to cardioplegic arrest 1 highlights the need for controlling reoxygenation during cardiopulmonary bypass. 1 the hatter cardiovascular institute university college london wc1e 6hx uk. 1 in most cases the machine is used to perform serious procedures that require the heart to be stopped.

However the clinical benefits appear to be more evident at higher doses of propofol as shown by ansley et al. Cardioprotection during cardiac surgery derek j. Recent studies have successfully demonstrated the benefits of this approach 2. 71 72 ischaemic postconditioning has been recently applied in the setting of cabg surgery at the time of aortic cross clamp removal when the patient comes off cardiac bypass and the heart is subjected to a period of global reperfusion.

Open heart surgery triggers an inflammatory response that is largely the result of surgical trauma cardiopulmonary bypass and organ reperfusion injury e g. Cardioprotection during cardiac surgery. Hausenloy edney boston griffiths and derek m. Hausenloy dj 1 boston griffiths e yellon dm.

Listing a study does not mean it has been evaluated by the u s. Previous article in issue next article in issue. More recently however a pig model of cardiopulmonary bypass and cardioplegic arrest demonstrated the cardioprotective action of propofol when used at clinically relevant concentrations lim et al 2005. Nitric oxide mediated cardioprotection during cardiac surgery with cardiopulmonary bypass noincpb the safety and scientific validity of this study is the responsibility of the study sponsor and investigators.

Pyruvate fortified cardioplegia mitigated myocardial injury during coronary artery bypass surgery and facilitated postsurgical recovery of cardiac performance. The mechanistic pathways underlying ischaemic postconditioning ipost cardioprotection are complex and some of them are similar to those utilized by ipc and are the subject of several recent reviews. Coronary heart disease chd is the leading cause of morbidity and mortality worldwide. The development of the cardiopulmonary bypass cpb revolutionized cardiac surgery and contributed immensely to improved patients outcomes 1 2.

It is a device that does the work of providing blood and oxygen to the body when the heart is stopped for a surgical procedure. The importance of anaesthetics. There is therefore a need to discover. Inflammatory response and cardioprotection during open heart surgery.